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KMID : 0191120100250060953
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Journal of Korean Medical Science
2010 Volume.25 No. 6 p.953 ~ p.956
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A Case of Multiple Endocrine Neoplasia Type 1 with Primary Liver Gastrinoma
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Lee Sul-Ra
Ahn Kyu-Jeong
Choi Moon-Chan
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Abstract
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Gastrinoma is the most frequent functional pancreaticoduodenal endocrine tumor in patients with multiple endocrine neoplasia type 1 (MEN 1). Primary hepatic gastrinomas in MEN 1 are very rare, with no previous reports published in the literature. We reported the case of a 39 yr old female patient with a history of repeated peptic ulcers and a hypoglycemia episode. Abdominal CT indicated a well-defined liver mass and a pancreatic head mass. Somatostatin-receptor scintigraphy with [111In] DTPA octeotride demonstrated a strong uptake of the radiotracer in the left lateral segment at the site of the hepatic mass. After operation, immunohistochemical staining was consistent with pancreatic insulinoma and primary hepatic gastrinoma. As the liver is a common site of metastases from gastrinoma, primary liver gastrinoma has not yet been reported with MEN 1. We diagnosed this patient using immunohistochemical studies and treated this patient by hepatic segmentectomy.
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KEYWORD
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Gastrinoma, Multiple Endocrine Neoplasia Type 1, Insulinoma
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